Stroke is the most common cause of death and disability from neurologic disease in humans. Activation of microglia and matrix metalloproteinases MMPs is involved in positively and negatively affecting stroke outcome. Novel, noninvasive, multimodal imaging methods visualizing microglial and MMP alterations were employed.
The spatio-temporal dynamics of these parameters were studied in relation to blood flow changes. The inflammatory response was spatially located in the infarct core and in adjacent penumbral tissue. For the first time, multimodal imaging based on PET, single photon emission computed tomography, and magnetic resonance imaging revealed insight into the spatio-temporal distribution of critical parameters of poststroke inflammation.
This allows further evaluation of novel treatment paradigms targeting the postischemic inflammation. Abstract Stroke is the most common cause of death and disability from neurologic disease in humans. Publication types Research Support, Non-U. Substances N,N-diethyl 2- 4- 2-fluoroethoxy phenyl -5,7-dimethylpyrazolo 1,5-a pyrimidinyl acetamide Pyrazoles Pyrimidines Radiopharmaceuticals Technetium Tc 99m Exametazime Matrix Metalloproteinases.
