Official websites use. Share sensitive information only on official, secure websites. EL performed the fMRI analysis and contributed to data acquisition. HM contributed to data acquisition, data analysis, and data interpretation. FF assisted with data interpretation. All authors critically reviewed content and approved the final version for publication.
Moreover, relatively little work has examined the relationship of AUD or CUD symptoms with face or expression processing within adolescents. Given the high prevalence of alcohol and cannabis use during adolescence, understanding how these usage behaviors interact with neural mechanisms supporting face and expression processing could have important implications for youth social and emotional functioning.
However, whereas this relationship was shown for AUD within ventromedial prefrontal cortex and lingual gyrus, it was shown for CUD within rostromedial prefrontal cortex including anterior cingulate cortex. Additionally, AUD symptom levels were associated with differential responses within medial temporal pole and inferior parietal lobule as a function of expression. These results have potential implications for understanding the social and emotional functioning of adolescents with AUD and CUD symptoms.
Adolescence is a time of rapid change in brain development particularly in networks important for social and emotional functioning; Kilford et al. Alcohol and cannabis use are highly prevalent during adolescence Johnston et al.
Multiple studies have linked substance use to impaired socioemotional function in adulthood e. One socioemotional function that seems particularly disrupted in adults by both alcohol and cannabis dependence is face processing, particularly of emotional expressions Castellano et al. Face and expression processing undergo considerable neurodevelopment from adolescence to adulthood Wu et al. As such, impairments in this processing have been linked to interpersonal difficulties in adults with alcohol dependence Kornreich et al.
