Official websites use. Share sensitive information only on official, secure websites. Acute respiratory distress syndrome continues to drive significant morbidity and mortality after severe trauma. Its pathophysiology includes the release of damage-associated molecular patterns DAMPs , which propagate tissue injuries by triggering neutrophil extracellular traps NETs.
NETs include a DNA backbone coated with cytoplasmic proteins, which drive pulmonary cytotoxic effects. Aerosolized dornase alfa was shown to reduce trauma-induced lung injury in experimental models and to improve arterial oxygenation in ventilated patients.
The secondary objectives are to demonstrate an improvement in lung function and a reduction in morbidity and mortality.
Randomization of patients per treatment arm will be carried out through a secure, web-based system. Statistical analyses will include a descriptive step and an inferential step using fully Bayesian techniques. Participant recruitment began in March Results will be published in international peer-reviewed medical journals. If early administration of inhaled dornase alfa actually reduces the incidence of moderate-to-severe hypoxaemia in patients with severe trauma, this new therapeutic strategy may be easily implemented in many clinical trauma care settings.
This treatment may facilitate ventilator weaning, reduce the burden of trauma-induced lung inflammation and facilitate recovery and rehabilitation in severe trauma patients. Registered on 11 December Keywords: Acute respiratory distress syndrome, Adult, Hypoxaemia, Multiple trauma, Deoxyribonuclease I, Neutrophil extracellular traps, Randomized controlled trial.
