Public Health , 04 December Infectious Diseases: Epidemiology and Prevention. As known, pneumococcal vaccination lowers the risk of IPD so the aim of this study was to investigate whether the introduction of pneumococcal vaccination has influenced the incidence and mortality of IPD in adults in Croatia.
Number of vaccine doses distributed were obtained from the healthcare system. Results: During the study period, patients were hospitalized, of whom The annual incidence of IPD ranged from 0.
A total of In Bacteremic pneumonia was the most frequent clinical presentation of IPD Also, 64 patients Serotype was determined in A total of isolates Discussion: The introduction of pneumococcal vaccination has led to a significant decrease in the incidence and mortality of IPD in adults. To further reduce morbidity and mortality from IPD, it is necessary to increase vaccine coverage in adults, particularly in individuals with risk factors. Streptococcus pneumoniae causes two groups of diseases in humans: invasive and noninvasive.
While the noninvasive forms of disease sinusitis, otitis media and non-bacteremic pneumonia are more common, the invasive forms bacteremic pneumonia, meningitis and primary bacteremia are more severe and in such cases, pneumococcus can be identified in primary sterile body fluids, such as blood, cerebrospinal fluid CSF or pleural effusion 1. In the adult population, bacteremia usually accompanies invasive pneumonia or meningitis.
The incidence of IPD in the population depends on many factors: patient age, comorbidities, vaccination status, serotype, season and geographical location. In the early s, a study was conducted in Croatia to assess the incidence of IPD in children. However, the incidence of laboratory confirmed IPD cases among Croatian adults during a fifteen-year period — was 1.
