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As an extract, it is mainly used recreationally and often illegally for its euphoric and rewarding effects. It is also used in medicine by Indigenous South Americans for various purposes and rarely, but more formally, as a local anaesthetic or diagnostic tool by medical practitioners in more developed countries.
It is primarily obtained from the leaves of two Coca species native to South America: Erythroxylum coca and E. It can also then be turned into free base form typically crack cocaine , in which it can be heated until sublimated and then the vapours can be inhaled. Cocaine stimulates the mesolimbic pathway in the brain.
Cocaine crosses the blood—brain barrier via a proton-coupled organic cation antiporter [ 18 ] [ 19 ] and to a lesser extent via passive diffusion across cell membranes.
A single dose of cocaine induces tolerance to the drug's effects. Addicts who abstain from cocaine may experience prolonged craving lasting for many months.
It also increases risk of stroke , heart attack , cardiac arrhythmia , lung injury when smoked , and sudden cardiac death. Coca leaves have been used by Andean civilizations since ancient times.