Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented. IP-mass spectrometry. MA detects the progesterone receptor PR from human, non-human primate, bovine, rat, rabbit, and mouse tissues.
This antibody does not cross-react with androgen receptor, estrogen receptor or glucocorticoid receptor. MA has been successfully used in Western blot, immunohistochemical and immunoprecipitation procedures. MA performs better by western blot using BSA as the blocking agent and in antibody diluent.
MA can be used with blocking peptide PEP The progesterone receptor PR is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation.
This deletion exposes a amino acid inhibitory domain ID that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements PRE sequences, resulting in activated transcription.
A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities. For Research Use Only. Not for use in diagnostic procedures.
